Background: Fumes generating during Soldering process comprise a group of fumes such as formaldehyde, tin (Sn) and Lead (Pb) metals. Studies showed some toxic effects of Soldering fumes on Respiratory and Nerve systems. The aim of the present study was to identify the toxic effects of Soldering fumes in liver of Rat in conditioned media in exposure chamber.Materials & Methods: 48 Rats were randomly divided into experimental (30) and control (16) groups. Each group according to exposure time to Soldering fumes was divided into 2, 4 and 6 weeks. Rats of experimental group were exposed to fumes in exposure chamber for 1h/day according to timetable. The amount of Sn, Pb and formaldehyde were measured (OSHA & NIOSH). Blood samples were collected from experimental and control groups according to timetable. The amount of ALP, ALT, AST, Total and conjugated bilirubin were measured. Collected data analyzed by SPSS software.Results: Although the amount of enzymes and bilirubin was different between control and experimental group, statistical analysis did not show any significant difference between control and experimental group. The amount of formaldehyde, Sn and Pb was 0.193 mg/m3, 0.35 mg/m3 and 3 mg/m3 respectively.Conclusion: It seems that with this time of exposure and fume concentration, Soldering fumes did not change LFT enzymes dramatically.