OBJECTIVE: THE COMPARISON OF INTRAOSSEOUS AND INTRAVENOUS INJECTION IN BIRDS.DESIGN:ORIGINALSTUDY ANIMALS-52PIGEON PROCEDURES-THE STUDY WAS DONE WITH CROSS METHOD. FIRST ALL BIRDS WERE DIVIDED TO TWO GROUPS RANDOMLY. GROUP A TAKED 20MG/KG THIOPENTAL: NA BY INTRAOSSEOUS ROUTE AND GROUP B TAKED INTRAVENOUSLY. AFTER ONE WEEK THAT NEEDS FOR WASHING OUT OF DRUG, GROUP A RECIVED 20 MG/KG THIOPENTAL-NA BY INTRAVENOUS ROUTE AND GROUP B RECIVED INTRAOSSEOUSLY. HEART RATE (HR), RESPIRATORY RATE (RR) AND CLOACAL TEMPERATURE (CT) WERE TAKED BEFORE (0 MIN) AND 1, 5, 10, 20 AND 30 MIN AFTER ANAESTHETIC DRUG ADMINISTRATION. AFTER INJECTION, NUMBER OF EFFORTS FOR INJECTING, DURATION TO ONSET THE ANESTHESIA AND DIFFERENT STAGES OF ANESTHESIA WAS CHECKED. RETURNING FROM ANESTHESIA IN TWO GROUPS WAS WRITTEN OUT AND COMPARED.RESULTS: STATISTICAL ASSESSMENT SHOWEDANESTHESIAONSET IN METHOD OF INTRAVENOUS INJECTION WAS SIGNIFICANTLY LESS THAN METHOD OF INTRAOSSEOUSINJECTION (P=0.003), AND RR IN TWO GROUPS WAS DIFFERENT IN 1 MIN AFTER DRUG ADMINISTRATION (P=0.036). THERE WAS NOT STATISTICALLY DIFFERENCE IN OTHER MINUTES FOR RR, HR AND CT IN TWO GROUPS (P>0.05). STATISTICAL ANALYSIS SHOWED THAT THERE WERE NO SIGNIFICANT DIFFERENCES IN TERMS OF NUMBER OF EFFORTS FOR ANAESTHETIZING IN BOTH METHODS OF INTRAVENOUS AND INTRAOSSEOUS AS WELL AS ANESTHESIA STAGE IN BOTH METHODS IN DIFFERENT MINUTES (P>0.05).ALSO NO SIGNIFICANT ALTERATIONS WERE RECORDED FOR RECOVERY TIME FOR BOTH GROUPS.CONCLUSION AND CLINICAL RELEVANCE: INTRAOSSEOUS INJECTION IN BIRDS IS COMPARABLE WITH INTRAVENOUS ROUTE.