SPIRO-COMPOUNDS REPRESENT AN IMPORTANT CLASS OF NATURALLY OCCURRING SUBSTANCES CHARACTERIZED BY HIGHLY PRONOUNCED BIOLOGICAL PROPERTIES [1]. THERE ARE SOME EXAMPLES OF BIOLOGICALLY ACTIVE SPIRO COMPOUNDS ON THE MARKET SUCH AS SPIPERONE, SPIROMESIFEN, ATIPRIMOD. DUE TO EXTENDED ACTIVITIES OF...

THE 3-SUBSTITUTED 4-HYDROXYCOUMARINS ARE INTERESTING HETEROCYCLIC COMPOUNDS BECAUSE OF THEIR BIOLOGICAL ACTIVITY AND THERAPEUTIC USE [1]. THESE COMPOUNDS, WHICH ARE WIDELY DISTRIBUTED IN NATURE, HAVE ANTIBACTERIAL, ANTI-HIV [2], ANTIVIRAL [3], ANTICOAGULANT [4], AND ANTIOXIDANT [5] ACTIVITIES, AND...

MODERN SYNTHETIC DESIGN DEMANDS HIGH EFFICIENCY IN TERMS OF MINIMIZATION OF SYNTHETIC STEPS TOGETHER WITH MAXIMIZATION OF COMPLEXITY [1]. ONE OF THE WAYS TO FULFILL THESE GOALS IS THE DEVELOPMENT AND USE OF MULTICOMPONENT REACTIONS WHICH CONSIST OF SEVERAL SIMULTANEOUS...

HETEROGENEOUS NANOCATALYSTS CONTAINING VARIOUS ACTIVE SITES ON THEIR SURFACE ARE PROMISING CANDIDATES FOR PROMOTING MULTIPLE REACTIONS IN A SINGLE POT.1 THE SOLVENT FREE CONDITION WHICH IS PROVIDING AN ECOFRIENDLY SYSTEM, HAS ATTRACTED A LOT OF INTEREST DUE TO MANY ADVANTAGES SUCH AS REDUCED POLLUTION, LOW COSTS AND SIMPLICITY IN PROCESS AND HANDLING...

BRØNSTED ACIDIC IONIC LIQUIDS ARE OF SPECIAL IMPORTANT BECAUSE THEY POSSESS SIMULTANEOUSLY PROTON ACIDITY AND THE CHARACTERISTIC PROPERTIES OF AN IONIC LIQUID. AMONG THEM SO3H FUNCTIONALIZED IONIC LIQUIDS ARE OF PARTICULAR VALUE, BECAUSE OF THEIR NEGLIGIBLE VAPOR PRESSURE AND OUTSTANDING ACIDITY. …

THREECOMPONENT REACTIONS OF SALICYLALDEHYDE, MALONONITRILE AND A SULFUR, CARBON, OR NITROGENBASED NUCLEOPHILES WERE DEVELOPED, BY USING PROLINE AS A CATALYST, WHICH GENERATED VARIOUS SUBSTITUTED 4HCHROMENE DERIVATIVES IN GOOD YIELDS. ...

MANNICH REACTION IS A ONE OF THE BEST METHOD IN SYNTHESIS OF B-AMINO CARBONYL.THIS REACTION IS A KIND OF MCRS THAT INCLUDES THREECOMPONENT REACTION OF AN ALDEHYDE, AN AMINE AND A KETONE FOR THE PREPARATION OF B-AMINO CARBONYL [1]. ...

IMIDAZO [1, 2A] PYRIDINE DERIVATIVES DISPLAY A DIVERSE RANGE OF BIOLOGICAL ACTIVITIES [1]. A NEW THREECOMPONENT CONDENSATION TO APPROACH SUCH FUSED IMIDAZOLES WAS DEVELOPED IN 1998 [2-4]. SINCE THE FIRST REPORTS WERE PUBLISHED, VARIOUS METHODS HAVE BEEN PERFORMED TO IMPROVE THIS POWERFUL MULTI COMPONENT REACTION SYNTHETIC METHODOLOGY. ...

BACKGROUND: PYRIMIDINE DERIVATIVES HAVE OCCUPIED AN IMPORTANT POSITION IN NATURAL AND SYNTHETIC ORGANIC CHEMISTRY, DUE TO THEIR WIDE RANGE OF BIOLOGICAL ACTIVITIES PARTICULARLY IN CANCER AND VIRUS RESEARCHES [1]. HEREIN WE REPORT A FACILE AND IMPROVED PROTOCOL FOR PREPARATION OF PYRIMIDINONE DERIVATIVES VIA THREECOMPONENT REACTION OF ALDEHYDES, N-UNSUBSTITUTEDAMIDINES, AND ETHYL CYANOACETATE UNDER THERMAL AQUEOUS CONDITIONS IN THE PRESENCE OF BISMUTH NITRATE PENTAHYDRATE AS CATALYST. (SCHEME 1).

MULTICOMPONENT REACTIONS (MCRS), AN IMPORTANT SUBCLASS OF TANDEM REACTIONS, ARE ONE-POT PROCESSES IN WHICH THREE OR MORE EASILY ACCESSIBLE COMPONENTS REACT TO FORM A SINGLE PRODUCT, WHICH INCORPORATES ESSENTIALLY ALL OF THE ATOMS OF THE STARTING MATERIALS. MCRS ARE HIGHLY FLEXIBLE, (CHEMO) SELECTIVE, CONVERGENT, AND ATOM-EFFICIENT PROCESSES OF HIGHEXPLORATORY POWER. WE DESCRIBE AN EFFICIENT, Three-component, AS PART OF CURRENT STUDIES, WE DESCRIBERESULTS OF OUR STUDIES INVOLVING AN EFFICIENT, THREECOMPONENT AND ONE-POT REACTION OF ISATOIC ANHYDRIDE AND NUCLEOPHILES SUCH AS ALCOHOLS AND THIOLS IN THE PRECENCE OF PHENACYL BROMIDES TO PRODUCE THE NEW CARBOXYLIC ACID DERIVATIVES. THE PRODUCTS WERE CHARACTERIZED ON THE BASIS OF THEIR ELEMENTAL ANALYSES AND THEIR IR, 1H NMR, 13C NMR AND MASS SPECTRA.