Introduction: Regarding side effects of acute and especially chronic inflammation and incomplete treatment of patients who suffering from these side effects, the new and affective strategies are needed. For this purpose in the present study, we scientifically evaluate an introduced folk herb Utica Dioica, for treatment of inflammation.Material and Methods: The Sham, control and treatment groups (rats which received the extract) were subjected to four methods in order to measurement the inflammation. In first method, an inflammation was raised by injection of formalin in hind paw. Then, the passed Evance blue dye injected to the circulation in wrist cutting paws segments were evaluated by spectroscopy method. In the second and third methods xylene and acetic acid were applied to ear and peritoneum, respectively. However, light absorption of the solution separated from ear segments solution and fluid of the peritoneum was read as the data. In forth method the difference weight of cottons which implanted in groin border of rats, before and after 7 days were compared in control and treatment groups.Results: Statistical analysis has shown a significant difference between rate of inflammation in control and treatment groups. The extract in doses of 50 and 100 mg/kg could reduce inflammation produced by formalin 24.52±2.2 and 22.71±2.1% (P<0.05), respectively. However, three doses of the extract (20, 50 and 100 mg/kg) have significantly reduced the peritonitis produced by acetic acid application in peritoneum, 21.45±2.4, 18.55±2.2 and 27.49±1.8% respectively (P<0.05). In the experiments on the ears there was find no significant effects for any doses of the extract on acute inflammation produce by xylem. Findings in chronic inflammation examination showed that the extract in doses over than 400 mg/kg could have diminished inflammation 24.08±2.1% (P<0.05).Conclusion: This study show that alcoholic Urtica Dioica extract could markedly reduced the chronic and acute inflammation.