Introduction: Ramadan is a special period of year that any Moslem had to go during fasting for one month. In healthy state there is a balance between psychic and bodily structure which is specific to each individual that distinct him from other people. Many researchers believed that neuroendocrine system maintain such balances. In this paper we have studied situation of neuroendocrin function in the pattern of cortisol secretion in Ramadan.Method & material: With above data we have selected 112 volunteers (80 mail & 32 female) after one month fasting in point's of cortisol circadian rhythm, and the results were compared to 8 patients with Cushing syndrome. We have checked these volunteers as the below: Weight, Height, Morning& Evening serum cortisol, CBC and 2mg Dexamethazone test (2mg every 6 house for 6 doses).Results: Although fasting during Ramadan did not promote obesity in healthy peoples, But in 20 volunteers, we found that evening cortisol raised to 18 mcg/dl it, that is not a serious problem and we think that this is an adaptation phenomenon.Conclusion: Since the endocrine system, which has broad-spectrum effects, control cellular and skeletal actions, the soundness of neuroendocrine system will be provided trough parasympathetic nerve (to control cathecoJamines, hypothalamohypophysis, endorphins and enkephalin) so we believed that this cortisol changes is due to adaptation phenomena to control emaciation in fasting people.

As a neurotransmitter or neuromodulator, brain histamine has a variety of physiological roles in brain functions such as hypothalamic- pituitary- adrenal (HPA) activity. Histamine induces the release of ACTH through the activation of hypothalamic neurons containing vasopressin and CRH. Histamine induces the activity of HPA axis directly or indirectly. Endogenous opioids modulate the (HPA) axis activity as well. In order to consider the interaction between morphine and pyrilamine in HPA axis, the adult male Wistar rats were administered morphine (0.5, 1, 1.5, 3 mg/kg), and pyrilamine (1, 5, 10, 20 mg/kg) respectively. Thirty minutes after injection, the rats were anesthetized and blood samples were collected for hormonal investigations. The result showed that morphine dose-dependently and also pyrilamine decreased the cortisol concentration in the serum. The treatment of morphine and pyrilamine together decreased cortisol level significantly and there is a close correlation between pyrilamine and morphine in cortisol secretion.