Background and purpose: Coronal CT scan of paranasal sinuses with contiguous images is the gold standard technique in diagnosis of sinusitis. Considering the expense and high dose of radiation in conventional CT scan, clinical measurements and simple radiography is not enough sensitive and specific, some workers have suggested limited screening (non contiguous) instead of conventional CT image. This study compared the diagnostic accuracy of coronal CT with limited screening (4 screens) to conventional CT in diagnosis of sinusitis.Materials and methods: On 100 patients suspected of sinusitis referred to Emam Khomeini hospital. Coronal CT scan (with 16 screens) was performed. And on the basis of relevant scout view, four images of limited screenings (non contiguouse images) were selected and printed. Images of the both CT techniques were reported seperately by two radiologists. (Totally, four CT reports for each patients were given) The results of standard and limited screening CT reports given from the first radiologist were compared with the reports of the same, given by the second radiologist.Results: The comparitive results for the standard and limited screening techniques reported by two radiologists referred to as kappa value were 0.95 and 0.97 respectively. Which indicate a good aggreement between two radiologists in giving the reports of the images. Limited screening technique generally had the rate of 94.1% and 93.5% for sensitivity and accuracy respectively. General prevalence of sinusitis in the patients under study was 67%. Maxillar sinus was the most involved one with result of 98.7%.Conclusion: Limited screening CT technique for paranasal sinuses can be a proper technigue as a first evaluative measurement in the patients suspected for sinusitis. For this, can replace simple radiography. Advantage of this technique can be due to use of less dose of radiation, more speed of radiography and less expenses.

Site selection for rural sports-cultural centers is a complicated process which is based on qualitative and quantitative criteria. There are several appropriate decision making methods which can be utilized for a spatial purpose. In decision making process, the qualitative and linguistic criteria are as important as quantitative ones. Moreover, stakeholders! Consideration should be taken into account. Therefore, it is necessary to use methods considering both factors including linguistic variables as well as stakeholders. AHP and Fuzzy screenings are two methods used for modeling qualitative and linguistic variables. However, since AHP contains a hierarchical organization, it can present more reliable results. On the other hand, the Ordered Weighted Average (OWA) is more flexible in taking the priorities of the decision makers into account. Hence better results can be achieved by the combination of OWA with other methods. In this paper, fuzzy screening, AHP, and a combined method of AHP and OWA are used in order to select the most appropriate site for rural sports-cultural centers in Kani Bazar, located in the suburbs of Mahabad. The results show that the combined method presents more flexibility and higher performance. Furthermore, the result of sensitivity analysis carried out on the data reveals that the developed system demonstrates very high stability.

Background: Nowadays photoproteins are excellent reporter systems as they have virtually no background. The most commonly studied photoprotein is aequorin. But because of it’s low quantum yield and very fast reaction kinetic; this photoprotein assay don’t adapt for High-Throughput screening (HTS). Consequently, some researchers developed three improved photoproteins optimized for the generation of precise Ca2+ mobilization assays; photina, i-photina and c-photina. Although the total light release of these photoproteins is greater and their reaction kinetic is slower compared to other existing photoproteins, opening new opportunities for the application of flash luminescence assays in HTS. Recently, the three photoproteins by several companies such as PerkinElmer and Axxam have been commercialized. So, we selected i-photina which has the highest luminescence signal and good stability compared with two other photoproteins.Materials and Methods: Codon usage of i-Photina was optimized for both E. coli and mammalian cells. The encoding gene of i-photina was synthesized and overexpressed in E. coli. Then i-Photina was characterized and compared with aequorin.Results: i-Photina showed about a 14-fold higher bioluminescence signal than aequorin. Ca2+ sensivity of i-Photina was found to be slightly less than aequorin. In respect to other measured properties such as degree of stability, bioluminescence spectrum and decay half-life time, these two photoproteins were almost the same.Conclusion: i-Photina is an improved version of photoprotein that in many ways is superior to use of other Ca2+ indicators for HTS assays and can also be considered as a potential candidate for creating genetic mutations improved the bioluminescence propertises.

Background: In 2015, in Csongrá, d County (Hungary), a general practitioner based colorectal screening model program was implemented by the financial support of the European Union. Our aim was to evaluate the indica-tors of screening program and to analyze the experiences and attitude of participants of colorectal screening pilot program. Methods: The colon cancer screening pilot programme was carried out in 2015 involving an average-risk pop-ulation aged 50-69 in Csongrá, d county, Hungary (invited 22 130 persons). The screening method was iFOBT, the attendance rate was 51. 2%. Overall, 5580 patients out of the 10374 participants completed the self-compiled questionnaire concerning socio-demographic data, current screening programs, stool sampling problems, invita-tion letters, information sources and future willingness of participation. Results: The response rate was 53%. 46. 7% of the respondents had not heard about colorectal screening prior to the screening program. Participants with elementary education level mostly indicated physicians as primary information sources [OR: 2. 72 (CI: 1. 59-4. 66)] than patients higher education level. 67. 5% of patients decided alone about participation on screening. Among women, decisions supported by acquaintances were specific [OR: 2. 05 (1. 06-3. 95]. 82. 6% determined the iFOB test as an entirely accepted screening method. Medical advice is an important predictor of screening participation. If respondents were to receive an invitation after two years, 91. 5% would be involved in the screening. Conclusion: The respondents were satisfied with the screening program. Awareness raising of men, lower ed-ucated patients, those living in major cities, and recommendation of the family physician may increase the par-ticipation rate in the future.