Optimization of the sectional wing in ground effect (WIG) has been studied using ahigh order numerical procedure and response surface method (RSM). Initially, the effects of the ground clearance, angle of attack, thickness, and camber of wing have been investigated by a high-resolutionscheme, which is highlystrong and accurate. In the numerical simulation, Normalized Variable Diagram (NVD) scheme is applied to the boundedness criteria. In the optimization process, lift to drag ratio (L/D) is considered as an objective function and static conditions and shape parameters are noticeable to be considered as design variables, Ths is because the main factor in the design of WIG vehicles is moving near the ground and the distance to the ground draws attention to the significance of it.Therefore, the static conditions strenuously defend this view that they are irrefutable parameters in the aerodynamic optimization of WIG vehicles. Adaptive Neuro-Fuzzy Interface System (ANFIS) is employed to generate the surface response, because the objective function and constraints are particularlynoisy. Sensitivity analysis is also done and the sensitivity amount of the objective function from design variables is explored.