Introduction: Rhabdomyolysis can be a symptom of COVID-19, with very few cases described so far. AKI and renal failure following rhabdomyolysis are a potentially dangerous complication. Diagnosis of rhabdomyolysis in COVID-19 is difficult due to overlap.Materials and Method: The present study was a PICO review that examined rhabdomyolysis in COVID-19. The documents browsed by Google Scholar, Sid and Mag Iran databases were analyzed using the keywords rhabdomyolysis, creatine kinase, COVID-19, acute renal failure.Results: Rhabdomyolysis following COVID-19 and SARS-CoV-2 reports of viral contamination of striated muscle may result in muscle destruction. Rhabdomyolysis in COVID-19 is a late complication. Evaluation of CK and myoglobin levels is important for the diagnosis of rhabdomyolysis in COVID19 patients. The mechanism of rhabdomyolysis in COVID-19 is unknown and various mechanisms are used.Conclusion: Rhabdomyolysis may cause acute kidney damage (AKI). Prompt diagnosis is a prerequisite for successful treatment and prevention of complications.