Assessment of aquifer vulnerability and contamination is necessary for management, development and land use allocation, qualitative monitoring, pollution prevention and the groundwater protection. In this study, Degradetion and DRASTIC models using GIS technique (combining by Index-Overlay method) was used for assessment of Kashan aquifer land use and vulnerability impact on groundwater pollution. In prepared map of DRASTIC model, demonstrates determination coefficient of 26%, significant level of 0.05 with nitrate concentrations in aquifer and DRASTIC-LU model demonstrates significant level of 0.05 and determination coefficient of 31.5% by added land use (LU) layer. Based on this model was found 1.1 percent of aquifer has high vulnerability in northwest, west and south of aquifer due to land uses of urban, industrial and farmland, high net recharge, sand and high coarse grain material in impact of vadose zone, aquifer media, soil media. Also land uses of industrial, garden land, cropland, urban, dry farmland, moorland, grassland with rates of 10, 9, 8, 7, 5.5, 2.5, 2 respectively demonstrates most nitrate pollution effect on groundwater by the use of Degradation model and demonstrates inherent risk of 0.45 and significant level of 0.05 based on partial correlation.