Geographic information systems and remote sensing techniques have been increasingly applied in watershed runoff estimation in recent years. In this research, the runoff curve number map of Birjand’s Mansourabad watershed, eastern Iran, was prepared using geographic information system (GIS), landsat images, and the Indian remote sensing (IRS) images based on the factors of hydrologic soil group, land use, land cover, and the hydrologic conditions. The land cover map was determined using Normalized Difference Vegetation Index, (NDVI); the watershed land use map was produced by satellite data; and the hydrologic soil group map was produced using field survey and watershed soil, slope, geology, and land use maps. Results showed that during the period of 2002 to 2006, land coverage density has decreased and consequently the curve number of watershed and its runoff production potential has increased.