Introduction: The workers in Quarry and Stone Industries typically perform some tasks such as carrying and handling heavy loads frequently and for a long duration and are exposed to high risk of musculoskeletal disorders (MSDs). The aim of this study was to compare the prevalence of MSDs and the risk of work postures in workers of quarry and stone Industries. Materials and Methods: This cross-sectional and descriptive-analytical study was conducted on 63 workers of Stone Industries and 46 workers of quarries in Kermanshah. The required data were collected by Nordic standard questionnaire, Body map chart, and REBA method. The gathered data were analyzed by Independent t-test, Mann-Whitney, Spearman and Pearson tests. The significant level was considered as<0.05.Results: The most prevalent musculoskeletal disorders in both Stone and Quarry workers were related to low back and equaled to 54% and 39%, respectively. The mean (SD) of grand scores of REBA in Stone and Quarry workers were 9.06 (1.45) and 4.6 (1.18), respectively. There were significant correlations between age, work experience, and BMI with MSDs in stone workers. Moreover, significant associations were found between age and work experience with MSDs in quarry workers (p<0.05).Conclusion: The results showed that the risk level of REBA and prevalence of MSDs of stone workers were higher than quarry workers in the areas of shoulders, wrists, hands, lower back, legs, knees and ankles.