Background: Subacute sclerosing panencephalitis is a progressive neurological disease of children due to measles virus. Dementia, ataxia, myoclonus and focal neurological signs with a fatal outcome are seen in this disease. Anti-measles vaccination programs have substantially decreased the incidence of subacute sclerosing panencephalitis. Materials and Methods: Over a period of 14 years, between 1988 to 2002, thirty patients who had presented with neurological signs, were confirmed to have subacute sclerosing panencephalitis. The diagnosis was based on neurological signs, EEG findings as well as high titers of anti-measles antibody in the cerebrospinal fluid using ELISA. Results: The age range of the patients was 3-15 years with a mean of 7±1 years. Nineteen patients were male and 11 were female with a male 11 female ratio of 1.7. Myoclonus (24), convulsion (18), hemiparesis (10), ataxia and coma were the most common signs in order of frequency followed by cranial nerve involvement, athetosis and delirium. Conclusion: Cases of subacute sclerosing panencephalitis are being diagnosed in spite of anti-measles vaccination. This may be due to incomplete measles vaccination in our region.