A STUDY OF THE EFFECT OF DRUGS USED IN THE TREATMENT OF RHEUMATOID ARTHRITIS ON NITRIC OXIDE PRODUCTION OF PERITONEAL MACROPHAGES IN BALB/C MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AMIN R; KASHEF S.; ALIABADI E.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MEDICAL RESEARCH (JMR) Year:2002 | Volume:1 | Issue:2 Page(s): 11-18

Download Full-Text

Persian Verion

View:

934

Download:

Cites:

Information Journal Paper

Title

A STUDY OF THE EFFECT OF DRUGS USED IN THE TREATMENT OF RHEUMATOID ARTHRITIS ON NITRIC OXIDE PRODUCTION OF PERITONEAL MACROPHAGES IN BALB/C MICE

Author(s)

AMIN R | KASHEF S. | ALIABADI E. | Issue Writer Certificate

Keywords

RHEUMATOID ARTHRITISQ3

SULFASALAZINEQ4

CHLOROQUINEQ4

AZATHIOPRINEQ4

METHOTREXATEQ3

NITRIC OXIDEQ3

Abstract

Background: RHEUMATOID ARTHRITIS (RA) is a chronic progressive inflammatory disorder characterized by polyarthritis in association with various systemic symptoms. NITRIC OXIDE (NO) production is increased in serum and synovial fluid of RHEUMATOID ARTHRITIS patients and may be involved in the inflammatory process. The aim of the present study was to assess the effect of various drugs used in the treatment of RA on NO production and if this effect varies with respect to the drugs that were tested. Materials and Methods: Different doses (1-1000 µM) of METHOTREXATE, SULFASALAZINE, CHLOROQUINE and AZATHIOPRINE were administered to measure IFN-γ and reaction. Results: AZATHIOPRINE, CHLOROQUINE and SULFASALAZINE inhibited NO production in a dose-dependent manner. AZATHIOPRINE. reduced NO production at all drug concentrations (p<0.05). CHLOROQUINE and SULFASALAZINE reduced NO production when given at 10-1000 µM Correspondence: LPS-induced NO production in peritoneal macrophages of Balb/C mice. NO production was measured by Griess concentrations (p<0.05), but METHOTREXATE reduced NO production (p<0.05) only when given at a high (1000 µM) concentration. Conclusion: The results suggest that, NO inhibition by these drugs can be regarded as a mechanism of action of these medications in the treatment of RA.

Cites

No record.

References

No record.

Cite

APA: Copy

AMIN, R, KASHEF, S., & ALIABADI, E.. (2002). A STUDY OF THE EFFECT OF DRUGS USED IN THE TREATMENT OF RHEUMATOID ARTHRITIS ON NITRIC OXIDE PRODUCTION OF PERITONEAL MACROPHAGES IN BALB/C MICE. JOURNAL OF MEDICAL RESEARCH (JMR), 1(2), 11-18. SID. https://sid.ir/paper/105813/en

Vancouver: Copy

AMIN R, KASHEF S., ALIABADI E.. A STUDY OF THE EFFECT OF DRUGS USED IN THE TREATMENT OF RHEUMATOID ARTHRITIS ON NITRIC OXIDE PRODUCTION OF PERITONEAL MACROPHAGES IN BALB/C MICE. JOURNAL OF MEDICAL RESEARCH (JMR)[Internet]. 2002;1(2):11-18. Available from: https://sid.ir/paper/105813/en

IEEE: Copy

R AMIN, S. KASHEF, and E. ALIABADI, “A STUDY OF THE EFFECT OF DRUGS USED IN THE TREATMENT OF RHEUMATOID ARTHRITIS ON NITRIC OXIDE PRODUCTION OF PERITONEAL MACROPHAGES IN BALB/C MICE,” JOURNAL OF MEDICAL RESEARCH (JMR), vol. 1, no. 2, pp. 11–18, 2002, [Online]. Available: https://sid.ir/paper/105813/en

Related Journal Papers