Introduction: This research aimed to compare the extent of effectiveness of cognitive self-regulation and information technology training on the job satisfaction of the Ministry of Culture and Islamic Guidance of Iran employees. Methods: The statistical population consisted of all of the Ministry of Culture and Islamic Guidance of Iran employees, which were one thousand fifty staffs in Tehran according to the statistics office of this ministry in 2017-2018. Given the Quasi-experimental nature of the research, sixty employees randomly chose and matched based on the criteria of age, gender, and working background, then they were assigned into three groups, twenty persons for each. The first group was trained information technology, the second group was trained cognitive self-regulation, while the control group had received no training. The job descriptive index developed by Smith, Kendall, and Hulin1969 were applied to all groups. For data analysis, correlated t-test and covariance analyses were used and analyzed by SPSS 22. Results: The findings suggested that the difference between the experimental groups and the control group is at the level of 0. 001 significant. Both educational methods for information technology and cognitive self-regulation training caused job satisfaction enhanced, while no significant difference was observed between the experimental groups. P>0. 05 Conclusions: The results suggest that both pieces of training have had the same effect on job satisfaction, so it is recommended to all organizations authorities to take one of the approaches into account.