The study area, (Spharayen plain) is one of the sub-catchments of the central Kavir, in North Khorasan Province. According to decrease in groundwater quality in Espharayen aquifer particularly in recent years, this paper tries to consider the reasons for decreasing the groundwater quality in the southern parts of the study area. For this purpose, in December 2009 and July 2010 the number of 75 samples from water wells was collected and the values of pH, EC, and concentration of major ions measured and finally the EC map of study area drawn. The maximum, minimum, and average values of EC of collected samples are 14720, 661, and 3519, respectively. On the basis of field observations and EC map, the Espharayen aquifer has been divided into five hydrogeochemical areas. For each area the average of anions and cations, EC, saturation index of Halite, and HCO3/Cl were calculated and compared. Exception for HCO3, the values of all ions, EC, and saturation index of Halite in areas 4 and 5 were greater than those in other areas. To evaluate the prevailing cation and anion zones, the Piper diagram has been applied. The obtained results indicate that there is an intrusion of saline water to southern and southwestern of the Espharayen aquifer (4 and 5 regions). Considering the values of draw downs in the five-mentioned regions, it may be concluded that the main reason for intrusion of saline water in this aquifer is significant groundwater decline due to extra-exploitation from the aquifer.