Jentashapir Journal of Cellular and Molecular Biology
Year:2012 | Volume:- | Issue:SUPPLEMENT|Papers Count:9

Background: The aim of this research was to study the comparison of cognitive-behavioral therapy, cognitive-behavioral therapy with exposure and response prevention, drug therapy and control group on Obsessive-Compulsive Disorder.Methods: The research method was experimental with pre-post test and control group. The sample consisted of 48 obsessive compulsive patients who were matched from age, educational statues, duration of disease and other criteria considered in this research. Then randomly selected in to three groups as experimental and one group as control. The instruments were Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Moudsley Obsessive-Compulsive Inventory (MOCI). Also we analyzed the data by ANOVA and Tokey method.Results: The results indicated that cognitive-behavioral therapy, cognitive-behavioral therapy with exposure and response prevention, drug therapy significantly decreased the OCD symptoms (P<0.001). Also in long term period, the effect of cognitive-behavioral therapy with exposure and response prevention was significantly better than cognitive-behavioral therapy and drug therapy but there was not a significant difference between cognitive-behavioral therapy and cognitive-behavioral therapy with exposure and response prevention (p<0.001).Conclusion: Cognitive-behavioral therapy, cognitive-behavioral therapy with exposure and response prevention, drug therapy were effective on reduction of OCD symptoms; but in long term, CBT and CBT with exposure and response prevention was effective than the drug therapy.

Background: Varicocele occurs in approximately 15% to 20% of the male population and it is the most common cause of poor semen. It has been demonstrated that patients with varicocele have poor chromatin packing, DNA damage and nuclear anomalies than the healthy men. Therefore, the aim of this study was to evaluate sperm chromatin integrity and semen parameter in patients after nonmicrosurgical subinguinal varicocelectomy.Methods: This study evaluated semen parameters and sperm DNA integrity before and 4 month after nonmicrosurgical subinguinal varicocelectomy from 30 men with varicocele in center of infertility in Ahvaz Jundishapour University of Medical Sciences. Parameters of semen were evaluated with WHO criteria and sperm DNA integrity was analysed by aniline blue and toluidine blue. The slides were checked by light microscopy and to determine the percentage of mature or immature spermatozoa.200 spermatozoa were counted in each slide.Results: The percentage of positive aniline blue (AB+) and toluidine blue (TB+) significantly decreased following varicocelectomy (59.98% versus 57.08%, P=0.047 for TB+and 57.08%5 versus 43.91%, P=0.039 for AB+). Morphology, count and motility of sperm showed improving after varicocelectomy but motility of sperm was not considered statistically significant.Conclusion: This study suggests that nonmicrosurgical subinguinal varicocelectomy can improve human sperm DNA integrity and semen parameters in men with varicocele.

Background: The aim of the present study was the comparison of dysfunctional beliefs and personality traits between teachers with and without health anxiety in Andimeshk.Methods: The sample consisted of 60 participants with health anxiety and 59 participants without health anxiety. The variables were evaluated in two groups by the Health Anxiety Inventory (HAI), Cognitions About Body and Health (CABAH) and NEO-FFI.Results: The MANOVA showed there is difference (p<0.001, F=20.564) between groups. Differences between two groups were significant, in CABAH and beliefs relevant to catastrophizing interpretation of bodily complaints, autonomic sensations, bodily weakness, intolerance of bodily complaints, and health habits, also neuroticism, extraversion, agreeableness, and conscientiousness.Conclusion: The Catastrophizing Interpretation of Bodily Complaints, Autonomic Sensations, Bodily Weakness, Intolerance of Bodily Complaints, Health Habits, and Neuroticism scales of participants with health anxiety were significantly higher, whereas their scores of Extraversion, Agreeableness and Conscientiousness scales were lower. Two groups were not different on openness scales.

Background: Liver plays an important role in normal function of the body. Liver diseases are the most common diseases in Iran and other countries, nearly3 to 5percent of the population of Iran suffer from it. Liver protective agents are under intensive investigations and among them are the compounds that have natural origin and rich in antioxidant capacity. In this study, protective effect of date (Phoenix dactylifera) seed extract on liver hepatocytes of rat has been evaluated. Previously, it was shown that this extract could have antiinflammatory, anti-tumor and peptic ulcer protective effects.Methods: For this study instead of the negative control group (receiving carbon tetrachloride and carrying extract) and control (receiving carrier), groups 100, 500, 1000 and 2000 mg/kg of date seed methanol extract was evaluated.and orally taken twice daily for four consecutive day to Rat and noon the fourth day exposed to 0.5 ml/kg carbon tetrachloride intraperitoneally, Blood was collected on fifth morning and activities of AST (SGOT) and ALT (SGPT) enzymes were determined.Results: Evaluation of serum concentration showed that the mean concentration serum AST in negative control group, control and control groups with doses 100, 500, 1000 and 2000 mg/kg of extract respectively 780, 140, 730, 390, 235 and 160 IU/ml, and for ALT respectively, 680, 110, 530, 360, 195 and is 160 IU/ml.Conclusion: Evaluation of results showed that doses of 1000 and 2000 mg/kg date seed extract in comparison with negative control group, protective effect against toxicity caused by carbon tetrachlorideis acceptable. And this could be due to antioxidant's effects of date seed that can inhibit radicals created bycarbon tetrachloride.

Background: The goal of conducting present research is to test the effect of 12-weeks selected yoga exercise on selected physiological factors and blood sugar of patients who suffer from type II diabetes.Methods: In this semi-experimental research, from the females who have diabetes in Isfahan Township, 26 women with age range of (45-60) years old and weight rage of (60-91 kg) voluntarily and in access choice and were put in two groups of experimental 16 patients) and control (20 patients). experimental group within the period of 12 weeks (3 sessions in a week, each session 75 minutes) did a selected yoga exercise, Whereas control group had no regular and systematic physical activity. In this research, variables to be tested were blood sugar, plasma insulin level, systolic blood pressure and also weight, body mass index that before and after the exercise period these variables were measured. to analyze the data from the descriptive and inferential statistics (T-test for the difference between the means of the independent groups) were used. A significant level (p<0.05) was considered for all the examinees.Results: findings of research show a significant difference between average of, blood sugar, plasma insulin level and systolic blood pressure, among experimental and control groups, whereas this difference in weight and BMI in experimental and control groups was not significant (p<0.05).Conclusion: findings of research showed that a period of selected yoga exercise causes a significant improvement in blood sugar of patients having type II diabetes.

Background: In traditional medicine of Lorestan province, Oily extract of root of a plant known as Tashnehdary (Onosma chlorotricum) are used topically for wound healing. So far this plant has not been investigated for its biological activity nor for its components. Antioxidant activity is one possible mechanism helps healing process. These days with changing societies to high stress lifestyles, the amount of oxidative reactions in human bodies are increased, so causes verity of harms to human health. Modern societies are looking for natural resources especially plants instead of chemicals to prevent oxidative reaction damages. n-Hexan extract of the plant root will be a good estimation of oily extract uses in folk medicine. This study has focused on phytochemical investigation of antioxidant components of the plant root.Methods: Extract was performed using Soxhlet apparatus and was run over TLC silicagel plates using following solvent system: n-Hexane: Chloroform (10: 90). Separated components on TLC were tested for the antioxidant activity using DPPH solution. Phytochemical evaluation of active compounds was investigated by various spray reagents.Results: Active antioxidant components appeared as light spots in the pink background. Antioxidant components Rf=0.9, 0.7, 0.37, 0.21 and 0.13, Components with have phenolic, phenyl propanoid and terpenoid structure and Probably are naphtoquninoes and due to bibliographic information are alkanin, shikonin derivatives.Conclusion: This study confirms antioxidant activity of some components in the lipophilic extract of the root of Onosma chlorotricumand consequently may confirm its effectiveness in processes such as wound healing which antioxidant reactions are helpful.

Background: Electrospinning is an old technique established for the preparation of submicron polymeric fibers. Recently, electrospun nanofibers have shown several medical and pharmaceutical advantages due to their extremely small diameter and high porosity. They can imitate the extra cellular matrix (ECM), utilized as wound healing and protective dressing. Chitosan is one of the important biomaterials which has shown wound healing and antimicrobial properties. The main purpose of this study is to investigate the effect of solution properties of chitosan such as concentration, viscosity on nanofiber formation and morphology.Methods: Chitosan solutions (2 and 3% w/v), with three different molecular weights prepared in 2% acetic acid. The solutions mixed with a 10% w/v polyvinyl alcohol solution (1: 1 ratio) and analyzed for their viscosity. Nanofibers prepared with electrospinning technique and the morphology and diameter of resulting nanofibers were tested by scanning electron microscopy (SEM) and image analysis. Possible physicochemical interactions between PVA and chitosan also evaluated by FTIR and DSC analysis.Results: The results showed that the PVA solution has the highest viscosity and addition of chitosan decreases its viscosity. Eelectrospinning of chitosan solution by itself was impossible but addition of PVA could facilitate the process. SEM analysis revealed that PVA solution results in smooth fibers which were comparatively large in diameter. Increasing chitosan decreased the nanofibers diameter and caused the formation of beaded structures.Conclusion: The results indicated that Chitosan with<500cp viscosity seems to produce more uniform nanofibers.

Pica is an eating disorder that the person is interested in eating unusual material, no nutritional value, such as chalk, clay, starch and Ice. Religious and cultural issues, psychological, physiological and economic poverty can be some factors to induce this disorder. Pica is seen in a pregnant women, children, people with mental retardation and psychiatric disorders in patients with geophagea. The common complications are include lead, Phosphorus and Mercury poisoning, hypo and hyperkalemia.Parasitis infections, Intestinal obstruction and dental carries are common in these persons.Case Presentation: A 38 year-Old obese woman that referred with multiple and unexplained somatic pain, depressed mood, worry about weight gain and her body. She started geophagea following her problems that it been more severe after progression of illness. So that the patient has been eaten soil among and even instead of meals.Conclusion: In this study, it is concluded that stress can induce geophagea and stress management and resolve of emotional disturbances decrease these habits.

Knowledge of herbal medicine by the physicians and medical students is essential for patients’ consultation. Due to the increasing use of herbal medicine in obstetric and considering that according to studies almost half of the users of traditional medicine are women of reproductive age, assessing the knowledge and attitudes of midwives and midwifery students in this field is essential. This study was done in the second academic semester to determine the attitude of midwifery students of Ahvaz university of Medical Sciences about herbal medicine and its application in obstetric in 2012. The results of this study showed the interest in learning herbal medicine and a lack of academic training in this field. It was also found that a quarter of students did not know the application of herbal medicine in obstetrics. It seems that inadequate academic training and no access to a reliable source for herbal medicines can effect on the ability of midwifery students in the use of herbal medicine for treatment of patients.