The shortage of suitable quality water resources is becoming one of the main challenges in arid, semi-arid, and coastal zones, sorghum yield declines with an increase in salinity, but its Sensitivity to salts varies with the salt composition in Water and the plant growth stage. The possible use of the Caspian Sea water, which its salinity is well below that of open seas, is desirable for irrigation. This research was conducted to study the effects of salinity levels and irrigation levels and determine the most appropriate mix of sea water and drinking water on yield and yield components of sorghum in research field experiment at Gorgan University of Agricultural Science and Natural Resource during 2012-2013 growing season. A factorial experiment was conducted using a randomized complete block design with four replicates. Salinity levels were S1, S2, S3, S4, S5 0%, 25%, 50%, 75%, and 100% mixture of Caspian Sea water and well water) and three irrigation levels included as A1, A2 (1.5*A1) and A3 (2.5*A1) crop water requirement. The results showed that there was a significant difference in plant height, tiller number, shoot weight and leaf weight per plant (1% level).