The present study aimed at investigating the role of patience in predicting the difficulties in emotion regulation among university students.400 undergraduate university students studying at Shiraz University were recruited via multistage cluster sampling method. They completed patience scale and difficulties in emotion regulation scale (DERS). This study was a descriptive and correlational one and the data were analyzed using path analysis model. Results of the path analysis using the structural equation modeling in AMOS software showed that patience was a negative and significant predictor of difficulties in emotion regulation. Tolerance was negatively related with the non-acceptance of emotional responses, difficulty in doing goal-directed behavior, impulse control difficulty, and limited access to emotion regulation strategies. Furthermore, persistence was negatively associated with the difficulty in doing goaldirected behavior, lack of emotional awareness, and limited access to emotion regulation strategies. Moreover, there was a negative relationship between the component of consent, impulse control difficulty, limited access to emotion regulation strategies, and non-acceptance of emotional responses. Results of this study support the idea that patience plays an important role in reducing difficulties in emotion regulation. These findings have major implications for the patience training and for the important role of this moral virtue in the prevention of emotional dysregulation among students.