Heat stress is one of the main obstacles for crop production in many areas of the world including southwest of Iran. In order to evaluate the effect of heat stress on yield, yield component, and mopho-phenological traits of wheat, an experiment was conducted based on randomized complete block design under normal and heat stress conditions on 11 wheat genotypes including Yavaroos, Zagros, Chamran, Niknejad, Koohdasht, Alvand, Montana, M6, Kauz, Gohar and Durum-ch-89 at experimental field of Shahid Chamran University of Ahwaz during 2010-2011. The results showed that terminal heat stress caused significant reduction in days from sowing to heading (29%), days from sowing to maturity (35%), plant height (31%), peduncle length (27%), head length with awn (12%), head length without awn (15%), number of spikelet per spike (15%), number of grains per spike (19%), 1000 grain weight (14%), biological yield (37%) and harvest index (5%), and spike/m2 so that these effects resulted in a significant reduction in grain yield (41%). Results of this experiment confirmed that morpho-phenological traits were detected as important traits in heat stress studies but number of grains per spike and harvest index were recommended as the best traits for screening the heat tolerant lines. Kauz, Chamran and Alvand cultivars were able to maintain the grain yield under heat stress condition and suggested as tolerant cultivars. These cultivars are recommended for direct planting in warm areas or using in breeding programs for heat tolerance.