In this paper, the role of reaction mechanism in direct initiation of detonation is studied numerically. The combustion mechanism is presented using a three-step kinetics model, which consists of chain initiation, chain branching and chain termination. In this research, the role of chain initiation on the blast initiation is studied. To investigate the role of chemical mechanism, a characteristic time (t1) is defined for each step, which contains the effect of various kinetics parameters. Numerical simulation shows that extending the initiation characteristic time (t) causes an increase in the critical energy of direct initiation. To demonstrate the role of chain initiation on detonation initiation, shock pressure diagrams are presented for different values of t1, and also for various initiation energies (E0).These diagrams show that for smaller t1’s, kinetics has a more important effect than for larger values of t1’s. Also, it is shown that by increasing the initiation energy, dependence of minimum value of the shock pressure on t1is decreased. For large values of t1’s, the behavior of the wave in the critical initiation is almost independent of t1 thus, detonation behavior for a given Eonearly coincides with the respective t1’s. The relationship between a t1 and Eodepends on the value of t1. For small t1, this relationship is linear with a small slope, whereas for large t1, it is linear with a large slope.