This work is on the thermal decomposition of ammonium perchlorate activated by addition of commercial Magnesium oxide (MgO) nanoparticles. MgO nanoparticles were characterized by X-ray Diffraction (XRD) and Transition Electron Microscope (TEM) which shows an average nanoparticles diameter of 24 and 20nm, respectively. Also, TEM image shows that the MgO nanoparticles have a polyhedral shape. Furthermore, the catalytic properties of the MgO nanoparticles on the thermal decomposition of ammonium perchlorate (AP) were evaluated by Thermo-Gravimetric Analysis and Differential Scanning Calorimeter (TGA/DSC). This method showed in presence of 1, 2, 3 and 4 wt% of MgO nanoparticles, the thermal decomposition temperature of AP decreased by 102.42, 110.52, 116.47 and 121.96oC, respectively. Also, results imply that the heat decomposition of AP was increased by 420.64, 637.18, 647.69 and 821.33J/g in the presence of 1, 2, 3 and 4 wt% of MgO nanoparticles, respectively. The kinetics of the thermal decomposition of AP and catalyzed AP have also been evaluated using model fitting method.