From way back, man has believed that he has a higher origin, higher than the material world. According to most myths and religions and as a constituent element of old and modern anthropology, the ancestor of man used to reside in paradise, but as a result of sin, they fell in the earth. The present article attempts to consider the story of Creation, descriptions of habitat of Adam and Eve (Aden), the reason of their fall according to Bible, and to compare them with the old mythical beliefs of Middle East, especially the myths of Mesopotamia, Egypt and Iran. Also, the psychological and mythical views of Campbell, Freud, Jung, Tillich and John Gray are noticed. This comparative study shows that the symbols of snake, tree, woman, sin, fall from the paradise and preventing man from having divine attributes, especially science, power, and eternal life, have a similar function in the myths of Bible and Mesopotamia.