This study attempts to present the influence of new geopolitical developments in the boundaries of the Middle East. In the new era, geopolitics is an important factor in understanding the developments. So far, the Middle East has been defined on the basis of traditional studies of regionalism including the presence of superpowers and geographical criteria. For this, the region has been divided into some sections including Persian Gulf, CIS, East Mediterranean, North Africa, Caucasia, and Western South Asia. New developments have changed these divisions. But the classical regional studies cannot explain these developments.