Our aim in this article is to investigate Khajeh Nasir’s effective role in emergence, growth and development of triple paradigms of Islamic philosophy, that are, Masha’, Ishraq and al-Hekmah al-Motealiyeh. Thus, first we present a summary of the meaning of “paradigm” and then discuss Tusi’s role in the development of triple paradigms of Islamic philosophy. We believe that, by using an interactive approach, Khajeh Nasir has attained a new approach to understand the paradigms. He is the first thinker in Islamic world who created a constructive and effective interaction between two paradigms of Masha’ and Ishraq, and paved the way for the emergence of al-Hekmah al-Motealiyeh.This can be explained with regard to either the conceptualization of al-Hekmat al-Motealiyeh or epistemological approach. Al-Hekmah Al-Motealiyah was influenced a lot by Tusi.