In the present research, we aim to study the synthesis of some isotopes of Flerovium 287 114Fl, 288 114Fl, 289 114Fl and 290 114Fl in the island of stability produced in the nuclear fusion of Ca ions with 239Pu, 240Pu, 241Pu, and 242Pu nuclei and to investigate the effect of different directions of target nuclei on the parameters of the fusion barriers We show that the contact angles of target nuclei influence the parameters of the fussion barriers of 48Ca ions with Pu different isotopes; and also we obtain the parameters of the fusion barriers for the synthesis of 287Fl, 288Fl, 289Fl and 290Fl nuclei and compare them with each other. . Also, we show that the minimum necessary energies for the synthesis of287Fl, 288Fl, 289Fl and 290Fl nuclei are 184. 16 MeV, 183. 95 MeV, 183. 75 MeV and 183. 56 MeV, respectively. Finally, in the framework of the statistical model, we attempt to estimate the evaporation residue cross section for 286Fl, 287Fl nuclei after the emission of three and four neutrons from 290Fl nuclei, showing that in the statistical model framework the results of calculations are in agreement with the experimental data.