In arid and semi-arid areas, due to scarcity of surface water, groundwater resources have been considered. Especially in urban areas, due to increasing urbanization and city progress, the need for high-quality water has increased significantly. In this study, physicochemical characteristics of groundwater were studied in Mashhad city. TH, TDS, EC, important parameters, the restrictive cause was known for drinking. Thus, the spatial distribution of these three parameters has been investigated by using interpolation methods. Interpolation methods that investigated in this study, including Deterministic methods (IDW, and LPI) and the Geostatistical (kriging and Cokriging) respectively. After Variogram analysis, the best method selected based on minimum RMSE, the process was used to locate contaminant. The results showed that the correlation was strong spatial parameters and Geostatistical methods to Deterministic methods indicating better results and Cokriging the method than other methods interpolation has had a significant advantage. Auxiliary variables used for EC and Cl TH parameters for EC and TDS parameters to increase estimation accuracy. Spatial distribution of pollutants showed that the southeast and northwest regions, based on the standard of drinking water, underground water is undesirable in terms of drinking. That were identified, the landfill area is urban. So due reduce the quality and increase groundwater pollution can be there Mozdoran formation and accumulation of municipal solid waste in these areas.