Sanctions have been the most controversial debate in Iran's foreign policy and economic relations during the last decade. The comprehensiveness and interweaving nature of sanctions created many difficulties for different political and economic institutions, and many obstacles for economic growth. The JCPOA deal and the country's entrance into international community entail many opportunities and positive consequences. This article studies Iran's economic crisis under sanctions which especially affected economic institutions like banks and then addresses economic challenges and opportunities facing Iran in the post-sanctions era. The main questions are that how sanctions affected Iran's economic situation, what are opportunities and challenges facing the country, and how Iran can use existing opportunities to ensure its economic interests? The authors believe that the JCPOA deal is a turning point in the I.R.I's politics and foreign relations which can create economic and political opportunities; however, it entails some challenges as well. It should be said that if after a ten year period of isolation, necessary conditions for joining international trade- an effort requiring sound planning, policy-making and monitoring- are not met, the economic system will face much more difficulties. Therefore, this article, while outlining losses made due to international sanctions, especially in international communications and trade sectors, introduces JCPOA document and its effects on different sectors, particularly economic institutions, examines opportunities and challenges facing the country in the period following the JCPOA deal, and present some recommendations regarding preparing the necessary for joining international community.