Dear editor-in-chief: Cancer considered as a serious disease in medical textbooks of “ Ancient Persia” , dates back to thousands of years ago. Among different types of cancer, the diagnostic and therapeutic methods of breast cancer was well-practiced and improved by Persian Medicine (PM) men, with some similarities to what experts do, nowadays, in Modern medicine1. PM, is one of the most important branches of Complementary and Alternative Medicine (CAM), rooted in more than seven thousand years ago studied by outstanding scientists especially those who lived in the golden age of Islam (9th to 13th century AD)2. Rhazes is one of the most distinguished PM scientists who lived in this era3. As other PM scientist, Rhazes believed that the body structure of human being is built on a four-humor basis, known as “ humoral theory” 4. To them, the quantitative and qualitative imbalance of these four humors lead to a variety of diseases, including cancer5, 6. The word “ Cancer” is derived from the Greek word “ Karkinos” , means crab, named after the apparent similarity of the cancerous masses with this crustacean7. PM scientists, like Rhazes, classified cancer in a category of diseases named “ Ouram-e-Solb” , described as a severe and hard swelling caused by the accumulation, congestion, inflammation, and finally stiffness of abnormal black-bile or “ Soda” (one kind of four humors) in any susceptible organ, such as the breast8, 9. As described in PM manuscripts, this kind of abnormal black-bile is initially produced in the liver and is not purged and purified adequately by the spleen, the organ naturally is responsible for it10, 11. A glance at the main medical resources in the past, one can find breast cancer going back to the “ Achaemenid period” (5000 years ago)12. By the passage of time, the issue was studied, and the related knowledge improved by prominent scholars such as Rhazes (865-925 AD), and Avicenna (980-1037 AD)13. As in Rhazes’ well-known book, “ Liber-Continent” , cancer in general, is more common in soft tissue-texture organs like the breast14. Moreover, compared to males, it is more common in females due to the presence of more soft tissue mass, (Rekhvat-e-abdaan)15.