Iranian Journal of Dermatology
Year:2015 | Volume:18 | Issue:4|Papers Count:10

Background: Cellulite is a common disease whose exact mechanism is unknown. This study was aimed to assess the safety and efficacy of an anti-cellulite preparation compared with placebo in a randomized double-blind, right-left comparison clinical trial.Methods: Twelve healthy women aged 22 to 58 years with mild to moderate cellulite on their thighs and buttocks participated in this trial. The anti-cellulite preparation (Three O cream, Pouya Varzan Tejarat Sepahan Co., Iran) and an identical placebo were randomly applied on the right or left thigh and buttock twice a day for 2 months. The mentioned areas were photographed and the circumference, subcutaneous fat thickness, and dermis density and thickness were measured before and after treatment.A satisfaction questionnaire was completed by all volunteers to assess their satisfaction with the efficacy of treatment on each side.Results: There was no significant difference between active and placebo treatment sides in any of measurements. About 90% of participants had an overall satisfaction of 5 and more than 5 based on a 0 to 10 visual analogue scale on the side of anti-cellulite cream. This score was similar on the sides treated with placebo and the active product.Conclusion: Although Three O cream provided more satisfaction in volunteers than placebo, the objective measurements did not show any difference between them.

Background: Cryotherapy is one of the most common and effective treatments of anogenital warts, and trichloroacetic acid is one of the methods commonly used. The aim of this study was to compare the effect of cryotherapy and trichloroacetic acid in thetreatment of anogenital warts.Methods: This randomized clinical trial was conducted on patients with anogenital warts. The patients were divided into two groups; one group was treated with liquid nitrogen and the other with 70% trichloroacetic acid. In both groups, the treatment was done every two weeks until complete disappearance of the lesions or for 6 sessions.Results: In this study, 68 patients with anogenital warts were studied. After the 6th session, the cure rate of in the patients treated with trichloroacetic acid (94.1%) was higher than the patients treated with cryotherapy (85.3%) (P>0.05).Conclusion: It seems that cryotherapy and trichloroacetic acid therapy have similar results in the treatment of anogenital warts.

Background: Pemphigus diseases including pemphigus vulgaris (PV) and bullous pemphigoid (BP) are autoimmune diseases that cause severe blistering of the skin and mucous membranes.Among inflammatory mediators, reactive oxygen species (ROS) are involved in the pathogenesis of a wide variety of diseases through oxidative stress for which protein carbonyl (PC) and total antioxidant capacity (TAC) are two important markers.Methods: We utilized PC and TAC in this study to compare the serum redox status of PV and BP patients with healthy subjects to investigate the possible role of oxidative stress in the pathogenesis of these diseases.Results: The serum PC level was significantly higher in patients (3.07 ± 1.57 mM) than the healthy controls (0.86 ± 0.24 mM) (P<0.01). The serum TAC was significantly higher in the patient group (3.45 ± 0.46 mM) compared with the healthy group (1.15 ± 0.05 mM) (P<0.01). Besides, both serum PC and TAC levels showed no significant difference between PV and BP patients.Conclusion: The findings of our study support the hypothesis that oxidative stress is involved in the pathogenesis of PV and BP.

Background: Mycosis fungoides is the most common type of primary cutaneous T-cell lymphoma. Its etiopathogenesis, despite numerous studies, remains unclear. Environmental, viral, and genetic factors have been proposed as its potential etiologic factors. In recent years, viral agents of herpes virus family such as human herpes virus 8 (HHV-8) have been noticed.Objective: The aim of this study was to evaluate the association between the presence of HHV-8 and mycosis fungoides.Methods: This case-control study was done on skin biopsies of 42 mycosis fungoides cases referred to the Department of Pathology, Imam Reza Hospital, Mashhad, Iran from 2004 to 2012, and 42 age and sex matched samples of melanocytic nevi.PCR was performed to detect HHV-8 in biopsy samples of the patients and the control group. Statistical analysis was done using the IBM SPSS Statistics (IBM Corp., Armonk, NY, USA) 20.Results: Of 42 patients with MF, 25 were male and 17 were female with a male to female ratio of 1.4. The mean age of the patients was 51.2 years. Most of the patients were in the age group over 60 years. Clinical lesions of the majority of the patients were papules and plaques. HHV-8 DNA was not found in any of the mycosis fungoides samples using the PCR method.Conclusion: Based on our study results, HHV-8 does not play an important role in the pathogenesis of mycosis fungoides.

Background: Erythroderma is an inflammatory disorder. It has various differential diagnoses, among which one of the most important is mycosis fungoides. Erythroderma itself can be a challenging disorder. Diagnosis of a mycosis fungoides patient presenting with erythroderma specially requires a careful assessment of the peripheral blood. Studies such as CD markers can lead to a more accurate diagnosis of mycosis fungoides.Methods: In this study, we evaluated ten erythrodermic patients in order to identify the source of their erythema. The underlying causes were both benign such as eczema, psoriasis, pityriasis rubra pilaris, acute generalized exanthematous pustulosis and malignant like hypereosinophilic syndrome and mycosis fungoided.Results: The CD4/CD8 ratio was greater than 10 in 2 out of 10 erythrodermic patients. These patients had decreased levels of CD7 and CD26 expression. While one of the two patients fulfilled the criteria of hypereosinophilic syndrome, the other one did not have a documented clincopathologic diagnosis and had a pathology report of lichenoid tissue reaction with eosinophilia in favor of drug reaction. Both patients had decreased levels of CD7 and CD26 expression.Conclusion: Since pathology is usually non-specific and cannot differentiate between the causes of erythroderma in erythrodermic patient with CTCL, peripheral blood findings including flow cytometry and the analysis of CD4/CD8, CD7, CD26 and CD27 expression are useful techniques which can be used for a prompt diagnosis.

This case report describes a patient with cutaneous signs in the genital and peri-anal region suspicious of Crohn’s disease without any intestinal symptom or sign. Inflammatory bowel disease can be associated with some cutaneous signs. However, in this paper, we report a patient with isolated cutaneous Crohn’s disease which is very rare (less than 100 case reports across the world).Our patient presented with inflammatory indurated plaques and sinuses in the genital region since 3 years ago. Colonoscopy showed no findings related to Crohn’s disease in the ascending, sigmoid, and descending colon, particularly the terminal ileum.The patient`s symptoms were relieved following treatment with infliximab. To the best of our knowledge, this is the first report of isolated cutaneous Crohn’s disease in Iran.

Pityriasis lichenoides is an uncommon, acquired, papulosquamous disorder that exhibits various clinical presentations, includingacute, chronic, and febrile ulceronecrotic Mucha-Habermann forms.Pityriasis lichenoides chronica (PLC) is the chronic form of this continuum. Its treatment is challenging for patients and clinicians and some cases are multidrug resistant. Today, this disorder has many treatment choices, including topical corticosteroids, topical calcineurin inhibitors, phototherapy (ultraviolet (UV) A and narrow band UVB), methotrexate, dapsone, cyclosporine and recently etanercept.In our experience, mycophenolate mofetil was effective as a new treatment for pityriasis lichenoides.

Psoriasis is a common chronic inflammatory skin disease. The most common form of psoriasis is characterized by sharply demarcated, scaly, erythematous plaques. The face is an unusual site for psoriasis.Herein, we report a 43-year-old woman with facial psoriasis that was developed after remission–induction chemotherapy for acute leukemia with high dose cytarabine/daunorubicin.

Chemical leucoderma is an acquired hypopigmented dermatosis caused by repeated exposure to specific chemical compounds, notably the aromatic or aliphatic derivatives of phenols and catechols which are commonly present in the rubber and plastic materials. Herein, we report a case of chemical leucoderma in a 55-year-old male, appearing bilaterally over the retroauricular areas, which appeared after of the use of a new spectacle frame by the patient. The patch test results with Indian Standard Series and Cosmetic Series were negative. Chemical leucoderma following the use of materials like hair dyes, and rubber shoes or gloves is common but only a few cases of leucoderma with spectacles have been reported in the literature to date.

Recent studies suggest that psoriasis may be an independent risk factor for the development of cardiovascular diseases. Myocardial infarction, pulmonary embolism, diabetes mellitus, hypertension, and dyslipidemia have been reported in patients with psoriasis. …