Background and Aim: The conventional procedure for removal of porcelain laminate veneers (PLVs) is time-consuming and inconvenient. The purpose of this study was to evaluate the efficacy of Er: YAG laser for debonding of PLVs. Materials and Methods: Forty-eight intact extracted human maxillary anterior teeth received discoid PLVs (24 feldspathic and 24 e-max ceramic). The PLVs had 0. 7 mm thickness and 4 mm diameter. After cementation of all PLVs with a light-cure cement, samples were stored at 37º C distilled water for 48 h. Samples of each ceramic were randomly divided into 3 groups of 8 samples. Then, laser was irradiated on the cemented PLVs as follows: (I) feldspathic PLVs without laser irradiation (control group), (II) feldspathic PLVs with laser irradiation (6 s, 10 Hz, 200 mJ, 2 W), (III) feldspathic PLVs with laser irradiation (6 s, 10 Hz, 300 mJ, 3 W), (IV) e-max PLVs without laser irradiation (control group), (V) e-max PLVs with laser radiation (6 s, 10 Hz, 200 mJ, 2 W), (VI) e-max PLVs with laser irradiation (6 s, 10 Hz, 300 mJ, 3 W). The shear bond strength of all samples was measured using a universal testing machine. We used Mann-Whitney and Kruskal-Wallis tests for data analysis (P<0. 05). Results: Laser irradiation decreased the shear bond strength of both ceramics. But this decrease was only significant for the e-max group (P<0. 05). No significant difference was found between different laser irradiation powers in the two ceramic groups. Conclusion: Er: YAG laser is effective for debonding of e-max PLVs.