This article tries to review Desert Fathers’ life, teachings and thoughts. Desert Fathers, such as Anthony the Great, St. Pachomius, St. John Cassian, St. Macarius, Origen, Simeon and etc, are considered as the real representatives of Christian monasticism. Among them, Anthony as the founder of the Eastern monasticism emphasized gnosis and St. Pachomius is remembered as a great collector of monastic rules. The concept of desert plays an important role in Desert Fathers’ literature, it also includes other elements such as emphasizing asceticism, poverty and worship. They believed that fasting, praying, hospitality and humility are the best ways for controlling the self. Moreover, their words are full of references to the mystical and theological teachings such as, trusting in God, believing in Trinity, loving Christ, loving poor people, reciting the Bible, patience, piety, self-control and etc.