Exegesis has usually been performed by two main methods: Methodical or Systematic, and Topic or Subject. The former has been prevailing since the very early times as most commentators and interpreters have applied it to interperet the Qur’anic chapters.The latter is relatively in his infancy in relation to the former, and though it is found in the words of the Holy Prophet and those of the pure infallible Imams (PBUT), it was the common method of interpretation among most Muslim scholars during the past centuries.During the 14th century, regarding the political and social transformations of the human societies including the world of Islam, most exegesis scholars were interested in the subject method more and more.Martyr Sadr is among those who consider the subject method inevitable for the Muslim scholars in the modern and contemporary world. He has a different view in this context with other interpreters. He believes that the subject method begins to form+ when a Muslim interpreter should begin with the real world before referring to the Holy Qur’an.The present paper is an attempt to study Martyr Sadr’s viewpoint in applying the subject method in exegesis based upon the discourse and speech with the Glorious Qur’an. His interpretation, as he suggests, is based on the Comander -of- The Faithful, Imam Ali (a.s.), in Nahjulbalqa, Calling for Muslims to discourse and speak with the Qur’an, so that in that manner, they should interpret the Holy Qur’an to suit the requirements of each period of the human societies to meet the needs and wants of community while speaking to them.