The history of tuberculosis, as a fatal disease, dates back to before 2000 BC In old civilizations, tuberculosis was a diagnosed illness one of its samples is Hamurabian Ac which data back to the civilization of Bein Al-Nahrein more than 2000 years ago. Previous physicians such as Hippocrates, Galen, Rhazes, Avicenna and other physicians in Egypt and China described the clinical picture of tuberculosis in their handwriting. However, its infective agent remained unknown until the last decades of 19th century, when Robert Koch discovered Then providing BC Vaccines, inventing Man to diagnostic test and appearance of anti-tuberculosis diseases caused much control over its prevalence. Despite significant advancements, tuberculosis was not totally eradicated like and is still a potential public health threat in developing countries. There are two difficulties to control it: It’s agent is very resistant against common medicine and appearance of such a disease in HIV-infected individuals. Presented here, is a brief review of the historical aspects of tuberculosis in the world and Iran, mainly during the 19th and 20th centuries.