ARCHIVES OF IRANIAN MEDICINE
Year:2021 | Volume:24 | Issue:4|Papers Count:12

Background: Poor oral health is common in the world, especially in low-income and developing countries. We evaluated oral health status and its association with sociodemographic and economic variables in one of the largest cohort studies in Iran. Methods: This cross-sectional study was conducted using data from the Pars Cohort Study which is conducted in a rural area in southern Iran. A total of 9264 individuals were enrolled in the initial registry. Data on sociodemographic and clinical characteristics were collected. Oral assessment was completed by trained physicians. Generalized negative binomial regression modeling was applied. Results: Overall, data from 9264 participants entered the final analysis. The participants’ mean age was 52. 6 ± 9. 7 years. In total, 8975 participants (96. 8%) had at least one tooth loss and 1790 participants (19. 3%) were edentulous. Female gender (incidence rate ratio [IRR]: 1. 05, 95% CI: 1. 02, 1. 08) (IRR: 1. 12, 95% CI: 1. 07, 1. 16), opium consumption (IRR: 1. 17, 95% CI: 1. 12, 1. 22) (IRR: 1. 23, 95% CI: 1. 16 1. 30), lower socioeconomic status (SES) (IRR: 1. 07, 95% CI: 1. 03, 1. 10) (IRR: 1. 10, 95% CI: 1. 06, 1. 15) and being illiterate (IRR: 1. 23, 95% CI: 1. 20, 1. 26) (IRR: 1. 36, 95% CI: 1. 32, 1. 41) were associated with higher decayed, missing and filled teeth (DMFT) and more tooth loss. Conclusion: Oral health was poor in our study sample, especially among older individuals, people with lower SES, illiterate participants, smokers and opiate consumers, which shows the need for improvement in oral health care.

Background: The outcome of patients with triple-negative breast cancer (TNBC) is highly dependent on demographic factors and ethnicity. We aimed to evaluate the clinicopathological determinants of prognosis among women with TNBC using data from one of the largest breast cancer (BC) registries. Methods: A total of 6145 patients with BC from our referral center were evaluated from 1995 to 2018, among whom 523 had TNBC. The baseline, menstrual and reproductive, treatment and pathology related characteristics were evaluated. Results: Among TNBC patients, the rate of stage 3 and 4 BC (29. 9% vs. 14. 4% and 7. 8% vs. 0% for stage 3 and 4, respectively; P < 0. 001), invasive ductal carcinoma (90. 7% vs. 75. 6%; P = 0. 004), nodal involvement (46. 7% vs. 33. 4%; P = 0. 026), mastectomy (57. 3% vs. 37. 8%; P = 0. 001) and axillary node dissection (76. 7% vs. 59. 8%; P = 0. 019) was significantly higher in the group that developed recurrence. Disease-free-survival was 80. 6% (157. 76 ± 9. 48 months) and overall-survival was 90. 1% (182. 73 ± 3. 28 months). For death, stage 3 BC (compared to stages 0 and 1 as base) showed a higher risk of earlier death (adjusted HR: 4. 191, 95% CI = 1. 392-12. 621; P = 0. 011). For recurrence, stage 3 BC (adjusted HR: 1. 044, 95% CI = 1. 209-6. 673; P = 0. 017) (compared to stages 0 and 1 as base) showed significantly higher risk for developing earlier recurrence. Moreover, those who had invasive ductal carcinoma (compared to other types of BCs) had a higher risk for developing earlier recurrence (adjusted HR: 3. 307, 95% CI = 1. 191-0. 724; P = 0. 012). Conclusion: BC stage plays a significant role in both earlier recurrence and earlier mortality among patients with TNBC.

Background: Intestinal failure (IF) is a life-threatening medical condition. The management of IF in low-and middle-income countries without home parenteral nutrition (HPN) remains unclear. We recently established an intestinal rehabilitation unit (IRU) and aimed to provide our experience on the current management and outcomes of IF in Iran. Methods: In this cross-sectional case series, data were collected from an established database on IF in the Shiraz Transplant Center in Abu Ali Sina hospital, affiliated to Shiraz University of Medical Sciences, Iran from January 2018 to October 2018. Results: Overall, 30 patients with a mean age of 44. 13 ± 10. 32 years, which included 25 males, were recruited. Short bowel syndrome (SBS) (60%) and enterocutaneous fistulae (27%), as complication of previous surgeries, were the main causes of IF. The most common type of IF was type 3 (67 %). Mesenteric ischemia was the leading mechanism of IF (47%). Fifteen patients (50%) received autologous gastrointestinal reconstruction surgery (AGIRS), and two (7%) patients had serial transverse enteroplasty (STEP). At the end of follow-up, 15 patients recovered from IF (50%). The overall survival rate was 83. 3%. Conclusion: This series introduced the results of a multidisciplinary program for the treatment of IF in a middle-income country that lacks facilities for HPN. Our protocol of care, understanding the need for development of HPN, showed promising clinical outcomes.

Background: The clinical significance of gastrointestinal wall thickening (GWT) on abdominal computed tomography (CT) is not certain, yet. Despite the need for clinical guidelines describing the importance and evaluation of GWT on a CT scan, there have been few studies evaluating these incidental imaging abnormalities. The aim of this study is to endoscopically evaluate certain etiologies that cause incidental GWT found on CT. Methods: This retrospective cohort study was carried out with patients who had incidentally detected GWT on a CT scan at the Kanuni Sultan Sü leyman Training and Research Hospital between February 2016 and December 2018. Results: A total of 129 patients (62 males and 67 females; mean age 57. 5 years, range: 26-87 years) were included in the study. Abnormalities observed during endoscopy at the exact site of the GWT noted on a CT image were found in 114 patients (99%): upper endoscopy revealed malignancy in 33 (29%), gastritis in 63 (52%), hiatal hernia in 19 (16%), a gastric ulcer in 7 (6%), and alkaline gastritis in 3 (2%). Colonoscopy revealed malignancy in 4 (33%), benign polyps in 5 (35%), colonic ulcer in 2 (16%), and 2 patients (16%) had normal findings. Malignancy was detected more frequently in the cardioesophageal region compared with the antrum (P = 0. 020). Conclusion: In this study, detection of GWT on CT often indicated pathologies which were subsequently confirmed endoscopically. Pathological findings were detected in 83% of these patients, with approximately 30% determined to be malignant. Endoscopic evaluation is recommended when GWT is reported on a CT scan.

Background: Ectopic adrenal tissue is a rare condition associated with embryological development defects seen in many different areas in the abdomen and pelvis. Here, we aimed to discuss the clinicopathological features of ectopic adrenal tissues diagnosed in our clinic, in light of the literature. Methods: We included cases of ectopic adrenal tissues incidentally detected in the specimens from patients undergoing operation for various diagnoses during 2012-March 2020. The cases were examined according to gender, age, location and accompanying pathological diagnoses. During this period, 15 cases of ectopic adrenal tissues (6 paratubal, 3 paraovarian, 2 paratesticular, 1 spermatic cord, 1 paraaortic, 1 liver capsule, 1 omentum) were detected accompanied by two endometrial carcinomas, two serous cystadenomas, one seminoma, one mixed germ cell tumor, one bilateral ovarian serous carcinoma and hepatic high-grade colon adenocarcinoma metastasis. Results: In this report, the fifth ectopic adrenal tissue accompanying a malignant testicular tumor, the fifth and sixth ectopic adrenal tissues occurring with ovarian serous cystadenoma, the first case observed with serous cystadenocarcinoma and the first case detected with hepatic adenocarcinoma metastasis are presented. Our cases are mostly women and adult men. Conclusion: Ectopic adrenal tissues can lead to hormonal problems and also to adrenal cortex and medulla neoplasms. Microscopically, they may be confused with clear cell gynecological and germ cell tumors. If the ectopic focus is misdiagnosed as an implant, a benign entity may be incorrectly reported as malignant. Also, it is important to prevent mis-staging in malignancies. For precise diagnosis, an immunopanel such as inhibin, melan A, and calretinin can be performed.

Background: Raised blood pressure is a serious risk factor for several non-communicable diseases (NCDs) in Iran. In this study, we aimed to estimate the mean of systolic blood pressure (SBP) and diastolic blood pressure (DBP) and subsequently, the prevalence of hypertension by sex, age, province, and year in Iran. Methods: We conducted a systematic review using PubMed, Web of Science, and Scopus databases through December 2017. We also used individual level data from eight national surveys, aggregated data from seven subnational population-based studies, and extracted data reported in 52 published studies. We used a two-stage model including Age-Spatio-Temporal and Gaussian process regression (GPR) to estimate mean systolic and diastolic blood pressure and used a crosswalk model to estimate the prevalence of hypertension by sex, age, province, and year. Results: The number of hypertensive adults increased in Iran from 1. 8 million (882 thousand in women) in 1990 to 13. 6 million (7. 2 million in women) in 2016. The national age-standardized prevalence of hypertension increased from 8. 7% (7. 8– 9. 7) to 28. 8% (27. 7– 30. 0) in women and from 8. 0% (7. 2– 8. 9) to 24. 2% (23. 1– 25. 3) in men from 1990 to 2016. Mean systolic and diastolic blood pressures show a similar increasing trend. Conclusion: During the past 27 years, we observed an increase in the age-standardized prevalence and mean levels of blood pressure. If the current trend in levels of blood pressure and prevalence of hypertension continue in the coming years, Iran will not achieve the sixth target of the Global Action Plan by 2020 and the Sustainable Development Goals (SDGs) by 2030.

Mesenteric fibromatosis (MF) is a rare, locally aggressive tumor without distant metastasis, which has a high recurrence rate. Based on its location, it is classified as intra-abdominal, from abdominal wall, and extra-abdominal. The incidence of cystic-solid, retroperitoneal tumors is very low in comparison to other MF forms. Intra-abdominal MFs are asymptomatic in early stages, but their symptoms appear late in the tumor course. There is no specific imaging finding since radiological diagnosis is mostly impossible. Thus, diagnosis is made histopathologically. Nowadays, there is no consensus about its treatment although surgical resection is widely used. In the present study, a very rare case of cystic-solid retroperitoneal MF associated with separate synchronous skin tumors is reported.

Malignant melanoma is a malignant neoplasm of the skin and mucosal tissues, and its behavior is not predictable. Thus, it could metastasize via mysterious routes. Here, we report a rare case of acute abdomen and acute appendicitis which involved metastatic malignant melanoma in a 63-year-old man without a history of previously treated malignant melanoma.

Background: Decision-making on allocating scarce medical resources is crucial in the context of a strong health system reaction to the coronavirus disease 2019 (COVID-19) pandemic. Therefore, understanding the risk factors related to a high mortality rate can enable the physicians for a better decision-making process. Methods: Information was collected regarding clinical, demographic, and epidemiological features of the definite COVID-19 cases. Through Cox regression and statistical analysis, the risk factors related to mortality were determined. The Kaplan-Meier curve was used to estimate survival function and measure the mean length of living time in the patients. Results: Among about 3000 patients admitted in the Taleghani hospital as outpatients with suspicious signs and symptoms of COVID-19 in 2 months, 214 people were confirmed positive for this virus using the polymerase chain reaction (PCR) technique. Median time to death was 30 days. In this population, 24. 29% of the patients died and 24. 76% of them were admitted to the ICU (intensive care unit) during hospitalization. The results of Multivariate Cox regression Analysis showed that factors including age (HR, 1. 031; 95% CI, 1. 001– 1. 062; P value = 0. 04), and C-reactive protein (CRP) (HR, 1. 007; 95% CI, 1. 000– 1. 015; P value = 0. 04) could independently predict mortality. Furthermore, the results showed that age above 59 years directly increased mortality rate and decreased survival among our study population. Conclusion: Predictor factors play an important role in decisions on public health policy-making. Our findings suggested that advanced age and CRP were independent mortality rate predictors in the admitted patients.

Since the emergence of novel coronavirus and the disease named as COVID-19 in late December of 2019 in Wuhan, Hubei province, China, many aspects of this disease have been reported in the literature (mainly pulmonary manifestations). In patients with COVID-19, rheumatic and cardiovascular manifestations and interactions were reported separately, but they were all very rare. This is the report of a 14-year-old teenager with GPA (previously known as Wegner’ s granulomatosis) who was in remission with immunosuppressive therapy. Post COVID-19 infection, she developed exacerbation of her disease. Besides the rheumatologic manifestations, she developed epigastric pain found to be acute myocardial infarction (MI) that needed primary percutaneous coronary intervention (PCI).

With interest, we read the article by Agha Abbaslou et al about a 55-year-old female with COVID-19 who developed the axonal type of Guillain-Barre syndrome (GBS), known as acute motor and sensory axonal neuropathy (AMSAN) 26 days after becoming symptomatic with the viral infection. . .

Thank you for taking the time to review our article. 1 Your comments are valuable to us and will help us to revise our future related papers. Below are some points in response to the comments made by you. The patient was admitted to our hospital during the peak stage of COVID-19 in our country. The decision for transferring the patient from ICU to the ward was made by our ICU managing team (including internal medicine specialists and anesthesiologists) because her respiratory situation was improved and she was extubated without any difficulties. Her O2 saturation was 92% with mask at the time we transferred her to the ward. . .