Global water scarcity and air pollution by greenhouse gases have amplified the need to use of unconventional water and environmental friendly materials in the concrete industry. Accordingly, the present study was conducted to investigate interaction of water quality (three levels including including tap water, treated industrial wastewater and the mixture of equal ratio of tap water and treated industrial wastewater), zeolite (four levels including 0, 10, 20 and 30 percent of zeolite application instead of cement in the concrete mix design), cement content (two levels including 250 and 350 kg. m-3) and curing age (including 3, 7, 21, 56 and 90 days) on concrete compressive strength. Regarding to the considerable types of the experimental treatments (120 treatment) in this research and with respect to the lack of statistical analysis in previous studies, the concrete compressive strength data of this study were statistically analyzed by analysis of variance and means comparison tests based on a completely randomized design with factorial experiment with three replications. The results of analysis of variance test showed that the simple effect of the investigated factors, their two-way interactions, except water type*curing age and zeolite *curing age, as well as the three-way interaction of cement content*water type*zeolite on the compressive strength of the concrete specimens were statistically significant. Due to the lack of significant negative effect of treated industrial wastewater and the mixture of equal tap water and treated industrial wastewater on the compressive strength of concrete, it is recommended to use these waters in the construction of plain concrete. However, the three-way interaction of water type with zeolite and cement content showed that the effect of investigated waters on compressive strength of concrete specimens in different percentage of zeolite is depended on cement content. So, the choice of the best application level of zeolite and water type according to the cement content should be selected based on the in-situ mix design test.