Objective: The main purpose of this study was to investigate the causal relationship between parent-child conflict, anxiety, loneliness and personal control as predictors of tendency to drug use in adolescents. Method: The research method was descriptive-correlational. The statistical population consisted of all addicted female adolescents in Abadan who were selected by voluntary sampling method as 200. Data collection instruments included the Tendency to Drug Use Questionnaire (Mousavi, Dustgharin and Roshanfekr Dezfuli, 1999), the Adolescent – Parent Conflict Scale-Short Version (Prinz, 1979), Self-Rating Anxiety Scale (Zhang, 1971) and the Revised Scale for Lonliness (Russell D, Peplau LA, Ferguson, 1978) and the Personal Control Scale (Berrenberg, 1987). Results: Path analysis showed that parent-child conflict, anxiety, loneliness had a positive and significant effect on tendency to drug use (P<0/05). The personal control path to the tendency to drug use was not significant (P>0/05). Conclusion: Considering the role of parent-child conflict, anxiety and loneliness in the tendency to drug use, by reducing parent-child conflict, anxiety and loneliness, we can present some solutions to control the tendency to drug use.