Background Divorce as one of the most determining factors in the disruption of the family as the most important social institution and the basis of society is of undeniable importance. The complexity and growing number of divorce in all societies highlights the need for the comprehensive investigation of the relevant underlying factors of this social dilemma. The present study aimed to explore the tendency for divorce based on marital burnout and tolerance of distress by the mediation of loneliness in female applicants for divorce in Kermanshah. methods The method of the research was descriptive and correlational which was conducted in the form of regression analysis and path analysis. The study population included all women seeking divorce in Kermanshah out of whom 100 samples were selected through availability sampling and asked to respond to research instrument. The data collection instrument in this study included marital Burnout Scale (MDS), Emotional Distress Tolerance Scale, and Social-Affective Loneliness Scale for Adults (SELSA-S). The resulting data were analyzed using mean and standard deviation at descriptive level and using the correlation test and regression analysis and path analysis at inferential level to reveal the mediating role by SPSS And Amos. Results Data analysis results revealed that the scales of marital Burnout and distress tolerance have a direct effect on loneliness. Conclusion As for the research results, the tendency for divorce among the applicants can be curbed through training and counseling concerning marital Burnout, tolerance of distress and loneliness in women.