Introduction: In the present study, the efficacy of an educational package was addressed based on increased cognitive, emotional, and neuro-muscular activity in depression in the elderly with mild cognitive impairment. Methods: In this study with pre-test and post-test design and control group, 30 of the elderly with mild cognitive impairment residing in Kahrizak elderly sanatorium were selected by simple sampling and randomly divided into two experimental groups. And control. Participants’ mini-mental state examination questionnaire, depression, and social isolation completed. A-18 rehabilitation sessions program was performed in over eight weeks and two to three weeks. Data were analyzed with analysis of covariance model. Results: The findings were that the experimental group received cognitive rehabilitation intervention, compared with the control group, based on the mental state examination scores (F=24. 30, P<0. 01) significantly better cognitive function; depression ratings (F=17. 67, P<0. 01) lower depression rates and according to social isolationist attitudes (F=25. 58, P<0. 01) less social isolation. Conclusion: The study results showed that increased cognitive, emotional, and neuromuscular activity is effective in improving cognitive function, reducing depression, and social isolation in mild cognitive impairment. Also, the partial square (effect size) for the effect of the independent variable on the dependent variable is 0. 524, which indicates that the independent variable explains 52% of the changes in the dependent variable. In other words, education based on increased cognitive, emotional, and neuromuscular activity has affected 52% of the daily performance of the elderly (MCI). Therefore; this designed training package can probably be designed as software that includes the combined effect of the variables of this research, and more people will be treated with this package.