Background and Objectives: Quinoa (Chenopodium quinoa Willd. ) is a species belonging to the family Amaranthaceae s. l., domesticated at least 5000 years ago in the Bolivian-Peruvian highlands. Quinoa is a nutritious herb with a favorable nutrition and potential for growth and production in adverse environmental conditions that can withstand salinity. Use of sea water in agriculture that will increase farmers' income, sustainable production and food security. Therefore, the goal of this study was to Investigation the effect of irrigation with seawater and freshwater on growth properties of Quinoa (Chenopodium quinoa Willd. ) in greenhouse condition. Materials and Methods: A pot experiment was conducted in greenhouse conditions at Gorgan University of agriculture science and natural resources, Iran, to evaluate the effectiveness of different moderation of using Caspian seawater for irrigation on growth and yield of Quinoa cv. Sajama. The research was done based on completely randomized design including 3 replications as pot planting during 2016. At sixth-leaf stage, plants were exposed to 5 saline irrigations treatments, i. e., control treatment (S1: 0. 5 dS. m-1 ), 15 (S2: 4. 3 dS. m-1 ), 30 (S3: 8. 0 dS. m-1 ), 45 (S4: 11. 8 dS. m-1 ), and 60 percent mixture of seawater and tap water (S5: 15. 5 dS. m-1 ). Salinity stress was gradually developed in pots with an increment of 15 percent of seawater until saline water for irrigated in each treatment on pots. After every-fourth irrigation, a micronutrient solution was added to irrigation water at a concentration of 1: 500 in each pot. After eighty-five days of germination, plants were harvested and plant height stem, leaf, and panicle fresh weights, no. of branches and inflorescence, grain and panicle yield, and 1000 kernel weight/plant. Shoot were oven dry for 48 h at 70 C and shoot biomass was recorded. Grains were collected from panicle to record 1000-grains weight and grain yield/plant. Results: The results inducted the effect of different moderation of irrigation regimes on the stem, leaf, and panicle fresh weights, grain and panicle yield, 1000 kernel weights, and plant height were highly significant (P<0. 01), but branches and panicle number were significant at 5 percent levels (P<0. 05). Results revealed that the increase of salinity of the water has an influence on some traits of growth and yield (stem, leaf, and panicle fresh weights, no. of branches and inflorescence, grain and panicle yield, 1000 kernel weight/plant, and plant height). The highest amount of 1000 kernel weights, grain, and panicle yield (4. 8, 15. 93 and 18. 52 gr) were measured at irrigation by freshwater. The result showed that the 15 and 30 percent mixture seawater freshwater irrigation regime compared to other regimes after control regimes had the highest of all of them. 15 and 30 percent mixture of seawater and freshwater has resulted in decreasing of 1000 kernel weights 22. 9 and 27. 1 percent, respectively. Conclusion: In conclusion, saline irrigation provoked a decrease in plant growth compared with non-saline irrigation; that meaning the morphological properties and yield of quinoa plant will be decreased due to salt stress. In conclusion, the highest values in most of the morphological traits were studied when using salinity irrigation water at a rate of 4. 3 dS m-1 to irrigate quinoa plant under greenhouse conditions, which proves that the quinoa crop resistant to salinity.