Given the fluctuations in world oil prices and the endless supply of this underground resource, the pharmaceutical industry is one of the attractive sectors of investment in intra-industry trade. Intra-industry trade refers to the simultaneous export and import of a group of similar goods, resulting in product differentiation in imperfectly competitive markets and the existence of economies of scale. The purpose of this study was to investigate the factors affecting intra-industry trade with selected drug trading partners for 2018-2000 using hybrid data method. According to estimates, research and development expenditures as an indicator of innovation have the greatest impact and have a positive and significant impact on trade within the Iranian pharmaceutical industry and selected trading partners, as well as trade imbalances and differences in GDP per capita. According to the Linder index, they also have a negative and significant effect, and by reducing these variables, intra-industry trade in the field of medicine will increase. On the other hand, the effect of geographical distance variable and FDI based on the effect of alternative, on the trade index within the industry has been negative and non-significant. The effectiveness of membership in the anti-fraudulent trade agreement, as a control variable, has reduced the level of trade within Iranchr(chr('39')39chr('39'))s industry with selected trading partners in the field of pharmaceutical industry.