Dear Editor, The Human Immunodeficiency Virus (HIV) serodiscordant relationship refers to mixed‑ status and condition in which one of the partners is HIV positive, while the other is HIV negative. It is anticipated that 75% and 37% of serodiscordant couples are living in countries with low and high HIV prevalence, respectively. They play a significant role in preserving the global HIV epidemic through sexual contacts. [1] There is a strong tendency towards conducting studies on HIV prevention that address couples as a unit for changing behaviors and interventions. [2, 3] There are two general strategies of service delivery in serodiscordant couples, including biobehavioral and biomedical categories, with emphasis on couple‑ based strategies. [3] SMART Couples, which stands for Sharing Medical Adherence Responsibilities Together, is a biobehavioral and couple‑ based approach for discordant couples with inadequate medication adherence in the HIV‑ positive partner. This approach educates couples about the significance of compliance to reduce viral resistance. The intervention involves cognitive‑ behavioral elements to identify barriers, promote healthy behaviors, and employing problem‑ solving techniques to identify and address adherence barriers. [4] Training on the importance of adherence to prevent viral resistance, health maintenance, recognition of non‑ adherence patterns, and increasing mutual social support for good health outcomes are core components of it. SMART Couples sessions for partners are better provided by a certified social worker or therapist, HIV case manager, health educator, or a nurse with experience of dealing with a dyad couple. [4, 5] The couple‑ based approaches in the service delivery process that emphasize healthy lifestyles, behavioral changes, and mutual supports can have positive consequences for the individual, newborn, family, and community. These approaches provide a context for couples to recognize their mutual responsibility to protect each other from transmitting HIV and to maintain each other’ s health. It also creates a safe environment to discuss sensitive issues such as sexual relationships using negotiation skills. It should be noted that for the effective implementation of couple‑ based approaches in real‑ world contexts, a cultural shift from focusing on individuals to dyad couples is needed, as well as the emphasis on addressing existing organizational and financial barriers. Financial Support and Sponsorship: Research Deputy, Mashhad University of Medical Sciences, Mashhad, Iran. Conflicts of Interest: Nothing to declare.