Modem age due to its epistemological virtue has a special important, since it defined a new relation between human and truth, in which some modem philosophers, like Descartes, Kant and Nietzsche have more roles. In this thought, human could take place as the center and criterion of understanding and interpretation of truth. In fact, human’s subjectivism has been of more important role in understanding the whole system of being. Descartes with his Cogito, mathematical method, rationalism and clear and distinctive conceptions, Kant with his a priori categories, Copernicus revolution; being axial of human reason in morality and religion, Nietzsche with his thought of Will to Power, nihilism and revaluation, and. Sartre with putting human in place of God, had a big role in taking place of human as center of truth and gradual evolution of subjectivism. The conclusion was and is consisted of neglecting and misunderstanding of metaphysical facts, religion and morality, and also of to restricted human to manage his/her mundane life.