Background and Aims: Micro leakage is one of the most common problems in bonding systems, which cause different clinical shortcomings such as post operative sensitivity, marginal discoloration and pulp necrosis that can decrease those using bonding systems. The aim of this study was to compare the micro leakage of three self etch bonding agents (generation 6 and 7) in class 5 composite cavities.Materials and Methods: In this experimental study, 30 facial class 5 cavities were prepared in 30 human premolar teeth which were freshly extracted for orthodontic purposes. Cl V cavities were prepared in 2*3*2 mm dimensions. Occlusal margins were in enamel and gingival ones in cementum and randomly divided into 3 groups of 10 each. Then the cavities were treated by clearhil SE Bond (Kuraray, Japan), G Bond (GC, Japan), and Opti Bond Solo Plus (Kerr, USA), according to the manufacturers’ insductions. Then the cavities were filled using Z100 resin composite. The specimens were then immersed in a 50% AgNo solution for 24 hrs. Then, the teeth were cut buccolingually to be evaluated for dye penetration with stereomicroscope. Data were analyzed using Kruskal-Wallis test.Results: This study revealed that Opti bond solo plus had type1 micro leakage (dye penetration up to 1.3 of cavity) in 80% of specimen, and type 4 micro leakage (along axial wall) in 10%. Clearfil SE bond had no leakage in 50%, type1 in 40% and type 2 (up to 2.3 of cavity) in 10%. But there was no significant difference in the micro leakage at the gingival margins between 3 groups (P>0.05).Conclusion: Clearfil SE Bond and G bond could prevent micro leakage more effectively than that of Opti Bond Solo Plus on the occlusal margins. However, no difference in the micro leakage on the gingival surfaces was found.