The 38-year rule of Sultan Husain Bayiqra (911-873 AH/1468-1505 CE), coinciding with the latter years of the Timurid reign as well as with the establishment of the Safavid state, is considerable in terms of how the Shi’I Islam was treated and what religious policies were adopted towards it. The general situation of Shi’ism in the Timurid period and, to some extent, the religious inclination of Sultan Husain and the religious milieu of this period, have been explored in the current researches. However, the present study, drawing upon the historical sources, biographies, letters, and writings of this period, in addition to the religious inclination of Sultan Husain and the religious situation of Shi’a within his sphere, seeks to examine and explain the causes of the Sultan’s tendency towards Shi’ism and the consequences which his religious politics had for it.