Background and Aim Despite improvements in medical therapy and standard care, exercise-based rehabilitation programs have been shown to have beneficial cardiovascular effects in patients with Myocardial Infarction (MI). This study aims to review the exercise-based cardiac rehabilitation strategies in patients with MI, focusing on the High Intensity Interval Training (HIIT). Methods & Materials This is a systematic review study. A search was conducted in reputable databases such as PubMed, Science Direct, Google Scholar, Scopus, and Springer on related studies without restriction of publication year using the keywords: “, microRNAs (miRNA) and myocardial infarction”, , “, cardiac rehabilitation and myocardial infarction”, , “, cardiac rehabilitation and High-Intensity Interval Training (HIIT)”, , and “, High-Intensity Interval Training (HIIT) and Myocardial infarction”, . Ethical Considerations All Ethical principles in writing were in accordance with the instructions of the National Ethics Committee and the COPE regulations. Results The HIIT is a safe and effective method to improve cardiac function in patients with MI. It exerts significant changes in molecular targets and cellular pathways to prevent abnormal changes in mass, size, geometry, and function of heart after MI. Conclusion HIIT protects the heart against adverse left ventricular remodeling after MI by targeting oxidative stress-induced myocardial necroptosis, and can be considered an integral part of post-MI cardiac rehabilitation programs.