In the study of the failure to expand and establish the Isma‘ili school in Maghreb, the impact and role of geographical factors, despite their importance, do not receive much attention. Given the firm relation between the historical phenomena and events with geographical factors (including the natural, humane, religious and political), the present research tries to explain the role and impact of these groups of factors in the failure of the Isma‘ili school to prevail in Maghreb during Fatimid period. The findings by this research show that the territorial extent and the environmental and geographical obstacles of Maghreb, made the domination of the Fatimid over its various aspects for laying the ground for establishing the Isma‘ili school impossible, just as for a long time it prevented the Muslims dominance in the conquests periods. At the same time, the human, religious, and political geography of Maghreb in pre-Fatimid period had been established in such a way that any of the religious Sunni (Maliki and Hanafi) groups, Kharigites (Safari and Abadi), and some pseudo-Islamic groups like Barqawāṭa, had their own territorial domains. In addition to this, the Fatimids, with their inability in establishing their desirable administrative-geographical divisions, failed to take under their control the administration of various regions of Maghreb. Thus, the geographical factors can also be taken into account as among the obstacles to the promulgation of the Isma‘ili school in the Maghreb during Fatimid period.