Aims and background: The coronavirus 2019 pandemic has caused psychological disorders in many people around the world, especially in vulnerable groups such as people with chronic diseases. In this regard, the present review study was conducted to investigate the anxiety, depression and stress of patients with rheumatoid arthritis and migraine during the COVID-19 pandemic. Materials and methods: In this study, a systematic review of the keywords COVID-19, Arthritis, Migraine Depression, Stress, Anxiety, Mental Health, Pandemic in the titles and abstracts of articles published in Google Scholar, PubMed, Scopus and Science Direct databases in the period 2020 (From February) to 2021 (until July) searched. 408 English articles were retrieved in the electronic search. The abstracts of the published articles were reviewed and, in several stages, duplicate and unrelated items were removed from the study, and finally 22 final articles were selected for comprehensive review and data extraction. The PRISMA checklist was used to review and control the quality of articles. Findings: Studies have shown a high prevalence of depression, anxiety, stress, poor sleep quality, recurrence and fear in people with rheumatoid arthritis and migraine during the COVID-19 epidemic. Factors such as female gender, age, rumination, marital status, income, education and disease severity were significantly associated with patients’,psychological health. The results of the studies showed that receiving social support, having physical activity, job and proper lifestyle led to improve the quality of life and mental health of patients with rheumatoid arthritis and migraine during the COVID-19 pandemic. Conclusion: Given that Coronavirus 2019 is still mutating and the psychosocial health of patients has been severely damaged. It is necessary to take measures such as tele-mental health to improve the mental health of patients in order to prevent recurrence of the disease and progressive problems.