Quality of life is a multi-dimensional concept that shows the general social, economic, and environmental features of regions. In rural regions, this concept expresses the conditions that indicate the degrees of individual and social-utilization, access, well-being, and welfare. The present research studied factors preventing the achievement of a desirable quality of life in border villages in Sistan, Iran, using a combination of field and descriptive-analytic methods. In this research, first, according to the number of villages in the study area, 43 villages were selected as sample villages using the Cochran formula. Then, based on the number of households in the area and re-use of the Cochran formula, 362 households were selected as sample families to complete the questionnaire. Research questionnaires were designed at two levels of household and village. Their content validity has been confirmed by the opinion of professors and experts, and the reliability of the questionnaires has been confirmed by Cronbach's alpha coefficient of 0. 86. Also, in analyzing the data, the limitations of achieving the optimal quality of life were investigated using the Analytical Hierarchy Process (AHP), spatial and statistical analyzes Expert Choice, SPSS and ArcGIS software. Based on the results of one-way ANOVA with repeated measures, there is a significant difference between the level of constraints in different dimensions of quality of life in the households, and the severity of the economic and environmental constraints of achieving the optimal quality of life, with a coefficient of 0. 337 and 0. 153, respectively, is more than the physical-skeletal and social constraints. In fact, the quality of life of the studied households depends on the border exchanges on the one hand and on the other on agriculture and its subdivisions, the former with the creation of the border wall and the closure of the border, and the other by a sharp decrease or stop continuously in the flow of water from Afghanistan, the drying up of the Hamoon wetland and the increase of the effects of sandy soils has reached a deadlock.