Background: Single suture craniosynostosis (SSC) is a disorder, affecting brain growth. Reviewing literature reveals controversialists of papers in this field. Methods: This prospective study was conducted from 2014 to 2016. All the individuals, aged 2 to 16 years, whose medical records files were complete, with SSC from 1999 to 2013 were included. All patients had undergone cranial vault remodeling at Mofid Hospital, Tehran, Iran. Wechsler questionnaires, WPPSIIII and WISC-IV, were completed for each child based on his/her age. Results: Seventy children were included, with the mean age of 6. 7 (±, 2. 9) years. Forty-six (65. 7%) children were boys while 24 (34. 3%) were girls. Mean FSIQ for all of children was 95. 5 (±, 13. 2). Mean verbal IQ, performance IQ, verbal comprehension, perceptual reasoning, processing speed, and working memory are 93. 4 (±, 14. 1), 96. 1 (±, 13. 3), 97. 5 (±, 13. 9), 102. 2 (±, 12. 5), 94. 5 (±, 9. 8), and 97. 5 (±, 12. 9), respectively. There was statistically significant difference between FSIQ of children with SSC and that of unaffected children (P-value<0. 05). There was significant difference between verbal IQ of children with SSC and that of unaffected ones (P-value< 0. 007). There was significant difference between in processing speed between affected children and unaffected children (P-value<0. 012). Conclusion: Children, aged 2 to 6 years, with SSC had a significantly lower Verbal IQ, and children, aged 6 to 16 years, with SSC had a significantly lower processing speed than their healthy counterparts. Though FSIQ of children with SSC falls within normal range, it is a little lower than healthy peers.