To evaluate the eco-physiological adaptation of many wheat genotypes against drought stress and determination of tolerant genotype, this experiment was carried out in Randomized Complete Block Design with three replications and 50 genotypes, under both irrigation and dry land conditions, in agricultural research station of Shirvan-chardavol in Ilam province, during cropping season 2010-2011. The results indicated that under dry land conditions, number of spikelet and 1000 kernel weight with seed yield had a positive significant (p<0.01) correlation. Under irrigation conditions, seed yield had a positive and significant correlation with number of seed in spike, height of peduncle, 1000 kernel weight and harvest index. Based on kernel yield of wheat genotypes at irrigation and dry land conditions, mean productivity (MP), stress susceptibility index (SSI), stress tolerance index (STI) and geometric mean productivity (GMP) were calculated. Regarding to this study indicated that MP, GMP and STI indices had the highest correlation with kernel yield and these criteria were recommended as desirable indices to determine the resistant wheat genotypes. In conclusion: Mohammadi, Cross-e-Sabalan and Sardari varieties were the best and most tolerance ones and had the highest yield under both irrigation and dry land conditions.